Sixty packages were discovered in a container from a ship that originated in South America - weighing 1,455kg.
The joint operation involved US Customs and Border Protection, the US Coast Guard, Homeland Security Investigations, the Drug Enforcement Administration, the New York Police Department and the New York State Police.
DEA special agent Ray Donovan said: "Cocaine, New York's nemesis of the 90s, is back, indicating traffickers push to build an emerging customer base of users mixing cocaine with fentanyl.
"This record-breaking seizure draws attention to this new threat and shows law enforcement's collaborative efforts in seizing illicit drugs before it gets to the streets and into users' hands."
NYPD commissioner James O'Neill said: "The proliferation of illegal drugs in New York City will never be tolerated, neither by law enforcement nor by the people we serve.
"The NYPD and its law enforcement partners remain committed to identifying and stopping all illegal narcotics by attacking their distribution networks on every level.
"Through significant seizures such as this, we will continue to make every neighbourhood in our nation's safest large city even safer."
No arrests have been made, and an investigation is ongoing.