The US president wants America to return to business by 12 April, as the coronavirus pandemic deepens.
"I would love to have the country opened up and raring to go by Easter," Trump said in a Fox News interview.
He was speaking as the US Congress neared the completion of a stimulus Bill that is expected to pump $2trn (£1.7trn) into the economy - with key votes due later on Wednesday.
Health officials and politicians warned against relaxing US restrictions too early for fear or even more deaths and a worse economic fallout.
And the mayor of New York, the region worst hit, directly contradicted the president, insisting things were going to get a lot worse.
But Trump said he believed if citizens continued to stay at home, the impact on society would be greater.
"This cure is worse than the problem," Trump said, adding that "in my opinion, more people are going to die if we allow this to continue."
US media reported that a White House official said the president does not believe he can reopen all businesses by Easter, but he can have the economy "speeding again".
Trump told Fox News later that he was targeting Easter because it was a "very special" day for him.
"You will have packed churches all over our country, I think it would be a beautiful time and it is just about the timeline that I think is right," he said.
He added that people could continue to practice good hygiene and social distancing even while going back to work.
Mr Trump's optimism was not shared by New York mayor, Bill de Blasio. The city has had more than 14,700 confirmed cases and over 130 deaths.
Speaking from City Hall Mr de Blasio said he respectfully disagreed with the president and that "we are looking at months and I'm going to say it again, because people deserve the honest truth that we are doing all we can just to get through March right now, particularly in terms of our health care system.
"April will unquestionably be worse than March. And right now, my fear is that May could be worse than April.
"That's the reality we're facing. I think the notion that we could be, quote unquote, back to normal in the month of April is absolutely inconceivable at this point.":