Manchester City, Liverpool, Manchester United and Tottenham await their fate, along with Barcelona, Juventus, Porto and Ajax.
England has four representatives at this stage for the first time in 10 years - and the draw rules mean the Premier League rivals could face each other.
David Moyes, Stuart Pearce, Chris Kirkland and Darren Bent will be in the Sky Sports News studio to react as the ties are made.
Click or tap the video above from 10.30am to follow the draw and watch reaction and analysis from the SSN studio.
Four English teams are in the Champions League quarter-finals for the third time - a feat never achieved by any other nation.